Nesma Nabil Mahrous, Dina Soliman Khater And Nermin Raouf,
ABSTRACT
Background: Ameloblastoma (AB) And Keratocystic Odontogenic Tumor (KCOT) Are Benign Locally Invasive Epithelial Odontogenic Neoplasms With High Recurrence Rate. Furthermore, Ameloblastic Carcinoma (ABC) Is The Malignant Variant Of Ameloblastoma With An Aggressive Behavior As Well As Poor Prognosis And High Recurrence Rate.
Aim Of This Study Was To Evaluate The Immunohistochemichal Expression Of Ezrin Antibody In These Epithelial Odontogenic Tumors Aggressive Behavior.
Materials and Methods: Immunostaining For Mouse Monoclonal Anti-human Ezrin Antibody Was Performed On 2 Tooth Germ (was Used As A Control), 15 AB, 10 ABC And 14 KCOT Archival Blocks.
Results: The Statistical Analysis Revealed The Highest Mean Area Of Ezrin Immunoexpression In ABC, While The Lowest Mean Value Was Recorded In Tooth Germs. It Also Revealed That The Difference Between All Studied Caeses Was Extremely Significant.
Conclusion: The Positive Cytoplasmic Immunoexpression Of Ezrin In AB, ABC, And KCOT Indicates That It It Could Be A Valuable Tool In Detecting Their Biological Behavior, Invasiveness And Progression.
